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President Biden started 2021 with a memorial for people lost to COVID-19. But his overarching pandemic message has shifted over the course of the year. We look at how and why.

Adele is the first female artist to have an album spend 10 consecutive years on Billboard's top 200. She's only the tenth artist to hit the milestone, joining the likes of Metallica and Bob Marley.

Opioids can kill because they reduce breathing along with pain. Now brain scientists have made a discovery that could lead to potent pain drugs that don't affect breathing.

Joseph Moore wore a wire for the FBI under his white robe.

The run on at-home COVID tests highlights some of the country's desperation in getting critical testing capacity up to speed. There are potentially some other roadblocks with other forms of testing.

University of Washington research predicts the omicron wave will infect more than 400,000 people a day in the U.S. when it crests in about six weeks.

Photographers from NPR's member stations across the country share memorable images from 2021. There are stories that document grief to ones that spread joy in a tumultuous year.

NASA's James Webb Space Telescope is waiting at its launch site, after years of repeated delays and cost overruns. At one point, the giant new observatory was threatened with cancellation.

NPR's Ailsa Chang talks with Matthew Brazzel, a Kentucky native who lost his home in deadly tornadoes on Dec. 10. Some of Brazzel's family photos have been found across the border in Indiana.

Five decades ago, the National Cancer Act became law. What did it take for cancer to go from an unmentionable disease to among the most visible and best-funded areas of medicine?