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A federal judge has overturned the $4.5 billion settlement between Purdue Pharma, which makes OxyContin, and the Sackler family, that would have protected the family from litigation of their own.

NPR's Rachel Martin talks to Sarah Ransome about her experiences with Ghislaine Maxwell and Jeffrey Epstein — accused of sexually exploiting minors.

The ruling Conservative Party in Britain has undergone a stunning defeat in a special election, in what is being seen as a personal blow to Prime Minister Boris Johnson.

Russia's government has released demands regarding security guarantees for Europe. The list, handed to a U.S. envoy in Moscow, amounts to a do-over of European history since the end of the Cold War.

Suzanne and Jesus Valle adopted six kids from Ohio families struggling with addiction, after raising nine of their own. At StoryCorps, the couple reflected on their unexpected shift in priorities.

First projections of the variant's impact find a range of possibilities, from just a relatively small acceleration of the current trajectory to a big new wave that could rival last winter's surge.

As the world reaches the terrible milestone of 1 million deaths from COVID-19, the countries with the highest death tolls are still struggling.

Of 2,000 people surveyed by a security firm, 81% say they're "anxious" about gun violence in particular.

The prolific author, poet, cultural critic, feminist and professor, who wrote more than three dozen wide-ranging books, died Wednesday at her home in Berea, Ky.

The Federal Reserve is opening the door to possible interest rate hikes earlier next year than had been expected, as it wrestles with the highest inflation in nearly four decades.