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Opponents to embryonic stem cell research point out its moral cost: the destruction of human embryos. Two couples discuss the different choices they made about the embryos they left at a fertility clinic.

NPR's Puzzlemaster Will Shortz quizzes one of our listeners, and has a challenge for everyone at home. (This week's winner is Dr. Steve Kleinman from Victoria, B.C., Canada. He listens to Weekend Edition on member station KZEA in Bellingham, Wash.)

One of the surprise critical hits of the summer is a new Paul Anka album. The teen-idol turned Vegas lounge singer puts a crooner's spin on rock classics, covering Nirvana and Van Halen, among others.

Gen. William Westmoreland, who commanded American forces in Vietnam from 1964 to 1968, died Monday night in Charleston, S.C. He was 91. Pulitzer Prize-winning author Stanley Karnow talks about Westmoreland and his insistence that the United States "did not fulfill its commitment to South Vietnam."

Wall Street Journal movie critic Joe Morgenstern tells Scott Simon about the movie Wedding Crashers, a comedy starring Vince Vaughn and Owen Wilson opening this weekend.

Rick Dawson, owner of Rich Strike and RED TR-Racing, said the horse will skip the next stop of the Triple Crown and get some rest before the third race in the series, the Belmont Stakes, in New York.

The nomination of top White House lawyer Harriet Miers to replace the retiring Justice Sandra Day O'Connor on the Supreme Court draws mixed reviews from both sides of the political aisle. Conservative Republicans aren't happy.

The Deep Dark: Disaster and Redemption in America's Richest Silver Mine tells the story of a deadly fire in Idaho's Sunshine Mine in May 1972. Scott Simon talks with author Gregg Olsen.

Oscar-winning singer/songwriter Jorge Drexler, who started out as a medical doctor in Uruguay, tells Jennifer Ludden about his rich cultural background, his eclectic muscial mix and the U.S. debut of his latest CD, Eco.

Wilt Chamberlain, a seven-foot-tall black man in a white man's NBA, changed professional basketball forever in one momentous night when he scored 100 points. Author Gary M. Pomerantz profiles a natural athlete with be-bop cool.